Paracetamol, a widely used painkiller, has been linked to liver damage, according to a recent study by the University of Edinburgh. This discovery sheds light on how the drug affects the liver and provides crucial insights into mitigating its harmful effects.
How Paracetamol Damages the Liver
The study revealed that Paracetamol can harm the liver by disrupting tight junctions, essential connections between liver cells. This disruption compromises the structural integrity of liver tissue, leading to impaired cell function and potential cell death. Although this mechanism of cell damage has been associated with various liver diseases, its connection to Paracetamol toxicity was previously unknown.
Research Implications
Researchers aim to develop alternative methods, using human liver cells, to study Paracetamol toxicity without relying on animal testing. This approach will enable a deeper understanding of how different doses and durations of Paracetamol exposure impact liver toxicity. Additionally, it may identify potential targets for new drugs aimed at mitigating Paracetamol-induced liver damage.
Study Details
Published in Scientific Reports, the study involved collaboration between researchers from the Scottish National Blood Transfusion Service, the Universities of Edinburgh and Oslo, and received funding from the Chief Scientist Office and the Biotechnology and Biological Sciences Research Council.
Significance of Findings
Dr. Leonard Nelson emphasizes the importance of these findings in understanding and preventing Paracetamol-related harm. While research on Paracetamol toxicity has a long history, recent advancements in biosensor technology offer promising avenues for elucidating its mechanisms, as highlighted by Pierre Bagnaninchi from the MRC Centre for Regenerative Medicine.
Proper Use and Dosage of Paracetamol
According to Mayo Clinic, the dose of Paracetamol varies for different individuals. It’s crucial to adhere to your doctor’s instructions or follow the directions on the label carefully. The dosage depends on factors like the strength of the medicine, the frequency of doses, and the duration of treatment.
For Pain or Fever
- For adults and teenagers: Take 650 to 1000 milligrams (mg) every 4 to 6 hours as needed. The dose depends on the form and strength of the medicine. Follow the label instructions for the maximum daily dose.
- For children: The dose is based on weight or age. Follow the label instructions for the maximum daily dose.
It is crucial to note that consuming more than 4 grams (4,000 milligrams) of Paracetamol in one day (24 hours) may increase the risk of serious liver problems. Always adhere to the recommended dosage and avoid exceeding the maximum daily limit to prevent adverse effects on liver health.
Disclaimer: This material, including advice, provides general information only. It is in no way a substitute for a qualified medical opinion. Take the methods, and claims mentioned in this article as suggestions only; DNP India does not confirm or refute them. Consult a doctor before implementing any such suggestions/ treatment/medicine/diet.
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